Vitamin C May Aid In COPD/Pneumonia Prognosis

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Growth velocity may therefore be a more sensitive indicator of systemic corticosteroid exposure in pediatric patients than some commonly used tests of HPA axis function. 
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Compared with controls, the mean AUC0-inf value was twofold greater in subjects with moderate (CLCR 30-50 mL/min) to severe (CLCR <30 mL/min) renal dysfunction. 
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They get up-to-date care from cancer experts, and they receive either a new treatment being tested or the best available standard treatment for their cancer. 
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It is not expected that dosage adjustment will be required in this population. 
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Reproduction studies performed in pregnant rats and mice given amoxicillin and clavulanate potassium for oral suspension and chewable tablets at oral dosages up to 1200 mg/kg/day, equivalent to 7200 and 4080 mg/m2/day, respectively (4.9 and 2.8 times the maximum human oral dose based on body surface area), revealed no evidence of harm to the fetus due to amoxicillin and clavulanate potassium for oral suspension and chewable tablets. 
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More than 90% of patients receiving a cisplatin dose ≥50 mg/m2 in the historical placebo comparator experienced vomiting in the absence of antiemetic therapy. 
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An open-label, long-term follow-up of 1133 patients for up to 52 weeks confirmed the minimal effect on the HPA axis (both basal and stimulated plasma cortisol) of inhaled budesonide when administered at doses ranging from 100 to 800 mcg twice daily. 
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This risk is reduced substantially if frovatriptan is not taken within 24 hours of taking an ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide).