Spinal Muscular Atrophy Drug Preclinical Efficacy Results - Oxford BioMedica

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Spasticity of Spinal Cord Origin: There were 16 deaths reported among the 576 U.S. patients treated with LIORESAL INTRATHECAL (baclofen injection) in pre- and post- marketing studies evaluated as of December 1992. Because these patients were treated under uncontrolled clinical settings, it is impossible to determine definitively what role, if any, LIORESAL INTRATHECAL played in their deaths. 
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The antihypertensive effect of enalapril maleate and hydrochlorothiazide tablets were usually sustained for at least 24 hours. 
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Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil. 
 
Several research studies are under way to try to find the exact causes of sudden cardiac arrest and how to prevent them. 
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Thus far, no reputable research has appeared to support any of these claims, except in cases of malnutrition. 
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One significant complication of flap reconstruction is fat necrosis, where a portion of a flap reconstruction has poor blood supply. 
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If bleeding persists or recurs, nonhormonal causes should be considered and adequate diagnostic measures taken to rule out malignancy or pregnancy in the event of breakthrough bleeding, as in the case of any abnormal vaginal bleeding. 
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When a patient is identified as having a drug addiction problem, referral for appropriate counseling may be considered (Class IIb, Level of Evidence C).